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Published on: February 17, 2023

4-Octyl Itaconate Promotes Diabetic Wound Healing by Enhancing Pro-Resolving Macrophages via the

Muhammad Junaid1, Yabin Zhu2

  • 1Health Science Center, Ningbo University, Ningbo, China.

Diabetes & Metabolism Journal
|July 14, 2026
PubMed
Abstract

No abstract available in PubMed .

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...