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DCTN2 and PAX8 levels in prostatic carcinoma tissues and their relationship with clinicopathological features and
Xiaolong He1, Haiqin Zhu2, Difu Fan1
1Department of Urology, The Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, China.
Objective:
To investigate the levels of dynactin 2 (DCTN2) and paired box gene 8 (PAX8) in prostatic carcinoma (PCa) tissues and their relationship with clinicopathological features and prognosis.
Methods:
A total of 103 patients with PCa admitted between February 2020 and February 2022 were selected as the study subjects. Immunohistochemical staining was used to detect the expression levels of DCTN2 and PAX8 in tissue samples. The associations of DCTN2 and PAX8 expression in cancer tissues with clinicopathological characteristics and prognosis were analyzed.
Results:
The positive expression rates of DCTN2 and PAX8 were higher in PCa tissues than in adjacent tissues (P<0.05). DCTN2 and PAX8 expression in cancer tissues was associated with clinicopathological features (P<0.05). DCTN2 and PAX8 expression in cancer tissues was related to tumor differentiation grade, lymph node metastasis, clinical stage, distant metastasis, preoperative PSA, and Gleason score (P<0.05). Tumor differentiation, lymph node metastasis, clinical stage, distant metastasis, preoperative PSA, Gleason score, DCTN2, and PAX8 differed significantly among patients with different prognoses (P<0.05). The 3-year progression-free survival rate of positive DCTN2 and PAX8 expression was lower than that of negative DCTN2 and PAX8 expression (log-rank χ²=9.656, 9.288, P = 0.002, 0.002). Lymph node metastasis, clinical stage, Gleason score, DCTN2 and PAX8 expression in tissues were factors affecting poor prognosis in PCa patients (P<0.05).
Conclusion:
The positive expression rates of DCTN2 and PAX8 were elevated in PCa tissues, and both markers were associated with the clinicopathological features and prognosis of patients.
