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Study on the mechanism of TP53 degradation by SFN ubiquitination affecting locally advanced TC progression

Ying Peng1, Bin Liu1, Ting-Ting Yang1

  • 1Thyroid Disease Diagnosis and Treatment Center, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Frontiers in Chemistry
|July 14, 2026
PubMed
Abstract

Insights

SFN protein promotes thyroid cancer metastasis by affecting cancer stem cell differentiation. Targeting SFN offers a potential neoadjuvant therapy to improve outcomes for advanced thyroid cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Locally advanced Thyroid Cancer (TC) presents a significant clinical challenge.
  • Understanding the molecular mechanisms of TC metastasis is crucial for developing effective therapies.
  • Neoadjuvant targeted therapy holds promise for improving patient prognosis and reducing operative mortality.

Purpose of the Study:

  • To elucidate the molecular mechanisms driving metastasis in advanced TC.
  • To explore the potential of targeting identified pathways for neoadjuvant therapy.
  • To improve clinical outcomes for patients with locally advanced TC.

Main Methods:

  • Serological tests to assess natural TF-Ab and TF-Ab sialacidification levels.
  • IP binding mass spectrometry to identify downstream proteins interacting with TF-Ag.
  • Clinical immunohistochemistry, in vitro, and in vivo experiments to validate target protein function in TC.

Main Results:

  • SFN (SFRS5) was identified as a key protein interacting with TF-Ag.
  • SFN expression is significantly elevated in locally advanced TC tissues compared to early-stage TC.
  • SFN regulates TC cell biological functions, CSC differentiation, and inhibits tumor progression in vivo.

Conclusions:

  • SFN-mediated TP53 degradation impacts CSC differentiation, potentially driving advanced TC metastasis.
  • SFN represents a promising molecular target for neoadjuvant therapy in locally advanced TC.
  • Targeting SFN could offer a novel strategy to improve treatment efficacy and patient prognosis.
Keywords:
SFNTP53advanced thyroid cancertumor metastasisubiquitination

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