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Updated: Jul 15, 2026
Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
Research progress and trends on DNA methylation research in non-small cell lung cancer: a bibliometric analysis
Mengmeng Chen1,2, Yaming Liu1,2, Fengfeng Xu1,2
1Department of Cardiothoracic Surgery, 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, China.
Background:
DNA methylation plays a key role in non-small cell lung cancer (NSCLC) pathogenesis. This study aimed to explore the global research landscape and frontier trends of DNA methylation and NSCLC through bibliometric analysis.
Methods:
A literature search was conducted in the Web of Science Core Collection (WoSCC), focusing on articles published from January 2008 to April 2025. The bibliometric analysis utilized VOSviewer, CiteSpace, and the R package "bibliometrix" to visualize collaborations, keyword co-occurrences, and emerging research trends.
Results:
The analysis identified 573 articles authored by 4,356 researchers across 2,524 institutions in 174 countries. China (n=288), the USA (n=77), and South Korea (n=33) were the countries with the highest number of published articles, with Nanjing Medical University in China (n=74) emerging as the leading institution. Clinical Cancer Research had the highest total link strength in co-occurrence networks. High-impact authors included Esteller Manel and Herman James G. Keyword clustering identified seven major themes: Hypermethylation in NSCLC, DNA methylation in therapy against NSCLC, DNA methyltransferases (DNMTs) in NSCLC, DNA methylation as a biomarker in early diagnosis for NSCLC, single nucleotide polymorphisms (SNPs) in NSCLC, cigarette smoke-related abnormal DNA methylation, and DNA methylation in other cancers. Notably, since 2022, the emergence of "activation" and "transcription" continued through to 2025.
Conclusions:
This bibliometric analysis highlights the important role of DNA methylation in NSCLC. Moving forward, research efforts should focus on elucidating the specific molecular mechanisms within the broader epigenetic network of NSCLC, rather than studying DNA methylation in isolation. Such an approach may enhance the efficacy of therapies targeting epigenetic regulators and modifiers.
