Related Experiment Video

Updated: Jul 15, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

Discovery of MK-2118, a Small-Molecule Agonist of STING

Timothy Henderson1, Michael D Altman1, Alexei V Buevich1

  • 1†Department of Discovery Chemistry; ‡Department of Quantitative Biosciences; §Department of Discovery Oncology; ∥Department of Pharmacokinetics; ⊥Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

ACS Medicinal Chemistry Letters
|July 14, 2026
PubMed

Keywords:
Drug DiscoveryImmunotherapyMK-2118OncologySTING

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