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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing more...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jul 15, 2026

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
10:04

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Published on: March 13, 2018

Future of radiotheranostics.

Akram Al-Ibraheem1,2, Serin Moghrabi1, Raghad Mohammad Al-Houwari1

  • 1Nuclear Medicine Department, King Hussein Cancer Center, Amman, Jordan.

BMJ Oncology
|July 14, 2026
PubMed
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Radiotheranostics combines imaging and targeted therapy for precision oncology. Advances in radionuclide science, AI, and dosimetry are paving the way for personalized cancer treatments.

Keywords:
Medical oncologyReceptorsSolid tumourSurvival AnalysisTumour biomarkers

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Radiotheranostics integrates molecular imaging with targeted radionuclide therapy using matched diagnostic-therapeutic radiopharmaceutical pairs.
  • Clinical successes like 177Lu-DOTATATE and 177Lu-PSMA-617 validate this approach, shifting cancer care towards evidence-based practice.

Purpose of the Study:

  • To review key developments in radiotheranostics, including molecular targeting, radiochemistry, dosimetry, and AI.
  • To outline priorities for translating next-generation radiotheranostics into clinical practice.

Main Methods:

  • Synthesis of key developments in molecular targeting, radiochemistry, dosimetry, and AI.
  • Review of emerging platforms targeting tumor-stroma and lineage-associated biology.
  • Discussion of advances in radionuclide science, including beta-emitters and alpha-particle therapies.

Main Results:

  • Established somatostatin receptor and PSMA paradigms are expanding to new targets like fibroblast activation protein.
  • Next-generation radionuclides and innovations in ligand engineering enhance therapeutic effectiveness and tumor retention.
  • Quantitative imaging, personalized dosimetry, and AI-enabled workflows support individualized treatment planning.

Conclusions:

  • Radiotheranostics is a rapidly evolving field with broad applications across diverse malignancies.
  • Continued advancements in technology and methodology are crucial for realizing the full potential of personalized cancer care.