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Risk Factors and Predictive Value of Sepsis in Patients with Liver Abscess.
Xiaoyan Ma1,2, Yanni Chen3, Xing An3
1Department of Critical Care Medicine, Yinchuan First People's Hospital, Yinchuan, Ningxia, 750001, People's Republic of China.
Infection and Drug Resistance
|July 14, 2026
Summary
Sepsis in liver abscess patients is linked to prior surgery, high creatinine, high bilirubin, and low platelets. A model using these factors aids early sepsis risk identification.
Area of Science:
- Hepatology and Infectious Diseases
- Critical Care Medicine
Background:
- Liver abscess (LA) is a serious condition that can lead to sepsis.
- Early identification of sepsis in LA patients is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To identify factors associated with sepsis in patients with liver abscess (LA).
- To assess the predictive value of these factors for early sepsis risk stratification in LA patients.
Main Methods:
- Retrospective analysis of clinical data from 798 LA patients.
- Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were used.
Main Results:
- Hepatobiliary surgery history, elevated serum creatinine (Cr), elevated total bilirubin (TBIL), and decreased platelet count (PLT) were independently associated with sepsis.
- A combined predictive model using TBIL, Cr, and PLT showed strong predictive performance (AUC = 0.848).
- Sepsis patients experienced longer hospital stays and higher 28-day mortality.
Conclusions:
- Sepsis in LA patients is associated with specific clinical and laboratory markers.
- A predictive model incorporating TBIL, Cr, and PLT can aid in early sepsis risk identification and clinical decision-making for LA patients.
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