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Deglycosylation at War: Host N-Glycoprotein Remodeling in Infection and Immunity
Xin Qian1, Jianjun Wang2, Yuxin Zhang1
1School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Infection and Drug Resistance
|July 14, 2026
Summary
N-glycan remodeling by hosts and pathogens critically impacts infectious disease outcomes. Understanding these dynamic interactions offers new therapeutic targets for infectious diseases.
Area of Science:
- Biochemistry and Molecular Biology
- Immunology
- Microbiology
Background:
- N-glycan remodeling is a key regulatory mechanism in molecular recognition and immune responses.
- The balance between host glycosylation and N-glycan remodeling influences infectious disease progression.
- Both host defense and pathogen offense drive N-glycan remodeling during infection.
Purpose of the Study:
- To systematically review host- and pathogen-induced N-glycan remodeling in infectious diseases.
- To elucidate the dual roles of N-glycan remodeling in microbial-host interactions.
- To explore therapeutic potential by modulating glycan remodeling processes.
Main Methods:
- Systematic review of existing literature on N-glycan remodeling in infections.
- Integration of evidence from enzymatic remodeling and glycan-processing models.
- Analysis of host- and pathogen-driven remodeling mechanisms and their effects.
Main Results:
- Host-driven N-glycan remodeling enhances immune recognition and pathogen clearance.
- Pathogen-driven N-glycan remodeling aids adhesion, immune evasion, and nutrient acquisition.
- N-glycan remodeling exhibits dual functionality, impacting infection outcomes differently based on its origin.
Conclusions:
- N-glycan remodeling is a critical determinant of infectious disease outcomes.
- Targeted modulation of N-glycan remodeling pathways presents a promising therapeutic strategy.
- Further research into glycan-mediated microbial-host interactions can advance anti-infective therapies.
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