Downregulated LINC02381 Predicts Tumor Progression and Correlates with Poor Survival in Gastric Cancer
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Dong Wang1, Jiahui Zhou1, Tangdan Ding1
1Scientific Research Centre, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
Purpose:
The elevated incidence and mortality rates of gastric cancer (GC) highlight the urgent need to identify novel prognostic biomarkers. In this study, we aimed to evaluate the expression of LINC02381 in GC tissues and its correlation with clinicopathological features, and to assess its prognostic significance.
Methods:
The expression of LINC02381 was assessed in 49 cases of GC tissues and noncancerous gastric tissues using real-time PCR. The correlation between the expression of LINC02381 and the clinicopathological parameters of GC patients was analyzed by in situ hybridization histochemistry (ISHH) in 78 GC tissues. Subsequently, univariate and multivariable Cox regression analysis, and Kaplan-Meier survival analysis were performed to correlate with clinicopathological variables.
Results:
We found the expression of LINC02381 was decreased in GC tissues (P<0.05) and was correlated with poorly differentiated GC (Grade III/IV) (P<0.05). Kaplan-Meier survival analysis showed that the low expression of LINC02381 was significantly correlated with the overall survival rate of patients for GC, GC patients with low expression of LINC02381 had a poor prognosis (P<0.05). Univariate Cox regression analysis showed the expression of LINC02381, tumor size, grade, T stage, and N stage were associated with the prognosis of GC. Multivariate Cox regression analysis revealed that N stage remained an independent prognostic factor.
Conclusion:
LINC02381 is downregulated in GC tissues, and its low expression is associated with malignant progression and shorter survival. Although not an independent prognostic factor, it may serve as a potential adjunct prognostic indicator for GC.
