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Related Experiment Video

Updated: Jul 15, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
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Subclinical Trigeminal Dysfunction in Multiple Sclerosis Detected by Pulp Sensibility Testing.

Kadriye Demirkaya1, Meryem Tuba Sönmez2, Duygu Arslan Mehdiyev2

  • 1Department of Endodontics, Gülhane Faculty of Dentistry, University of Health Sciences, Ankara, Türkiye.

Noro Psikiyatri Arsivi
|July 14, 2026
PubMed
Summary

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Pulp sensibility testing detected subclinical trigeminal afferent dysfunction in multiple sclerosis (MS) patients. This dysfunction was more pronounced in progressive MS, suggesting its utility in assessing trigeminal nerve health.

Area of Science:

  • Neurology
  • Neuroscience
  • Dental Research

Background:

  • Multiple sclerosis (MS) can cause subclinical trigeminal nerve dysfunction, preceding overt symptoms.
  • Early detection of trigeminal pathway disturbances is crucial for understanding MS progression.

Purpose of the Study:

  • To evaluate pulp sensibility testing for detecting subclinical trigeminal afferent dysfunction in MS patients.
  • To compare trigeminal afferent function between MS patients and healthy controls.

Main Methods:

  • Electric pulp testing (EPT) and cold stimulation were used on the maxillary central incisor.
  • Sensory threshold values (EPT) and response latencies (cold test) were recorded.
  • Thirty-nine MS patients and 27 healthy controls participated.
Keywords:
Cranial neuropathieselectric pulp testmultiple sclerosispulp sensitivity teststrigeminal nerve

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Main Results:

  • MS patients showed significantly prolonged cold response times and a trend towards higher EPT thresholds compared to controls.
  • Progressive MS patients exhibited more pronounced alterations in both EPT and cold response tests.
  • Disease duration correlated with EPT values, and age correlated with both measures.

Conclusions:

  • Pulp sensibility testing is a valuable tool for assessing trigeminal afferent pathway function in MS.
  • Findings suggest cumulative conduction disturbances in the trigeminal system, particularly in progressive MS.
  • Further research is needed to define the diagnostic value of this method compared to established techniques.