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Published on: March 20, 2026
Angiogenic Factors in Adult Diffuse Glioma and Their Correlation With Tumor Grade: An Observational Study
Vaishali Walke1, Soni S2, Amit Agrawal3
1Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Cureus
|July 14, 2026
Summary
Vascular endothelial growth factor (VEGF) and microvessel density (MVD) are linked to adult diffuse glioma progression. Targeting VEGF may offer new therapeutic strategies for high-grade gliomas.
Area of Science:
- Oncology
- Pathology
- Molecular Biology
Background:
- Angiogenesis, driven by vascular endothelial growth factor (VEGF), fuels adult diffuse glioma growth, progression, and metastasis.
- Gliomas exhibit vascular proliferation, impacting tumor behavior and patient outcomes.
- Microvessel density (MVD), assessed using CD34, quantifies the vascular response to VEGF.
Purpose of the Study:
- To investigate the relationship between VEGF expression, MVD, and histological grade in adult diffuse glioma.
- To understand the role of angiogenic factors in glioma progression.
Main Methods:
- A cross-sectional study of 50 adult diffuse glioma cases.
- Immunohistochemical staining for VEGF expression (scored 0-3) and CD34 for MVD assessment.
- Correlation of VEGF and MVD with CNS WHO histological grading.
Main Results:
- VEGF expression was detected in 44/50 cases, with overexpression correlating strongly with higher tumor grades.
- Elevated MVD (15-105 microvessels/10 hpf) was observed, also correlating with increasing tumor grade.
- Both VEGF and MVD were significantly associated with higher glioma grades.
Conclusions:
- VEGF expression and MVD are significant factors in adult diffuse glioma progression.
- Targeting VEGF offers potential for personalized therapies to improve outcomes in high-grade gliomas.
- Understanding these angiogenic factors is crucial for developing effective treatment strategies.
