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A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
Published on: June 10, 2022
Polyphenolic Components and Phytochemicals Deployed as Nutraceuticals and Pharmafoods
Subhash Chandra1, Md Sakib Al Hasan2, Md A K Azad3
1Department of Chemistry, School of Basic & Applied Sciences Shri Guru Ram Rai University Dehradun Uttarakhand India.
Polyphenols show promise in preventing and treating diseases due to their anti-cancer, anti-diabetic, and anti-inflammatory properties. This review highlights their medical, pharmaceutical, and nutraceutical applications, including their use with nanoparticles.
Area of Science:
- Nutritional Biochemistry and Pharmacology
- Medicinal Chemistry
- Nanomedicine
Background:
- Polyphenols are natural compounds with significant physiological health benefits.
- Their therapeutic potential spans various medical and pharmaceutical applications.
- Existing literature highlights the need for a comprehensive review of polyphenol applications.
Purpose of the Study:
- To systematically review the medical, pharmaceutical, nutraceutical, and dietary supplement uses of polyphenols.
- To summarize the therapeutic properties and applications of specific polyphenols (e.g., berberine, curcumin, EGCG).
- To discuss the role of nanoparticles in enhancing polyphenol pharmacological applications.
Main Methods:
- Systematic literature review conducted between 2010 and 2025.
- Searches performed across online and offline databases.
- Cochrane Risk of Bias tool (RoB 2.0) used for assessing randomized controlled trials.
Main Results:
- Identified polyphenols (berberine, EGCG, curcumin, luteolin, lycopene, apigenin, quercetin) effective against acute and chronic diseases.
- Documented anti-cancer, anti-diabetic, anti-inflammatory, anti-analgesic, anti-bacterial, and immunomodulatory properties.
- Nanoparticles show potential for improving polyphenol pharmacological applications.
Conclusions:
- Polyphenols are valuable therapeutic agents with broad-spectrum health benefits.
- They serve as potential adjuvants in treating various diseases.
- Further research into nanoparticle-based delivery systems is warranted for enhanced efficacy and safety.
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