Related Experiment Video
Updated: Jul 15, 2026
08:06
Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model
Published on: August 4, 2017
Research progress on functionalized stem cell therapy strategies in wound healing
Ting Ye1,2, Weihu Zhang1,2, Nanjian Xu2,3
1Department of Nursing, Ningbo No. 6 Hospital, Ningbo, Zhejiang, China.
Frontiers in Cell and Developmental Biology
|July 14, 2026
Summary
Functionalized stem cells offer promising solutions for refractory skin wound repair, including diabetic foot ulcers and burns. Optimizing these therapies may overcome challenges like immune rejection for better clinical outcomes.
Area of Science:
- Regenerative Medicine
- Biotechnology
- Wound Healing Research
Background:
- Refractory wounds like diabetic foot ulcers and severe burns pose significant clinical challenges.
- Conventional treatments (debridement, skin grafting) often fail to achieve functional skin regeneration.
- Existing stem cell therapies show promise but haven't fully achieved high-quality functional regeneration.
Purpose of the Study:
- To review stem cell sources for skin repair.
- To summarize key functionalization strategies for stem cells.
- To discuss advances in delivery systems enhancing stem cell engraftment and efficacy.
Main Methods:
- Literature review of stem cell sources in skin repair.
- Analysis of functionalization strategies for stem cells.
- Examination of advanced delivery systems for stem cell therapy.
Main Results:
- Functionalized stem cells regulate inflammation, angiogenesis, and tissue remodeling.
- Various stem cell sources are available for skin repair applications.
- Delivery systems are improving stem cell engraftment and therapeutic efficacy.
Conclusions:
- Functionalized stem cells represent a promising approach for skin injury repair.
- Immune rejection and variable efficacy are key obstacles to clinical translation.
- Multidisciplinary optimization of functionalization strategies is crucial for managing refractory wounds.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
01:17Stem Cell Culture
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
01:19Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
01:23Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
01:19Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...