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Updated: Jul 15, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Research progress regarding iminosugars for glycosidase inhibition and hypoglycemic activity
Chao-Na An1, Mei-Qi Yang1, Xin-Ran Song1
1College of Chemistry and Materials Science, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Hebei University Baoding 071002 P. R. China kerangwang@hbu.edu.cn.
None:
The multivalent effect or glycocluster effect is a natural phenomenon especially relevant for carbohydrate-protein interactions. Multivalent glycoclusters have been widely studied, and they show significantly stronger binding interactions with proteins compared with monovalent ligands. However, the development of multivalent glycoclusters based on iminosugars occurred relatively late. In this review, we systematically summarized the structural features and biological applications of monoiminosugars and highlighted self-assembled multivalent glycosidase inhibitors and their applications related to glucosidase inhibition activity, the hypoglycemic effect and antimicrobial properties. Finally, we outline potential applications of iminosugars in the development of long-acting hypoglycemic drugs and integrated functional molecules with both hypoglycemic and antibacterial activities.
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