Prospective Randomized Study of Visual Outcomes with Mini-Monovision Between the Light-Adjustable Lens and Clareon...

To compare binocular visual outcomes between the Light-Adjustable Lens (LAL) and the Clareon monofocal toric intraocular lens when both are targeting mini-monovision.

This was a prospective, randomized, double-arm, multi-surgeon study. Subjects were evaluated at 1 and 3 months postoperatively. Data collected included monocular and binocular uncorrected and distance corrected visual acuities at distance (UDVA, CDVA), intermediate (66 cm; UIVA, DCIVA), and near (40 cm; UNVA, DCNVA), higher order aberrations (HOA), administration of the Patient-Reported Spectacle Independence Questionnaire (PRSIQ), manifest refraction, monocular and binocular defocus curve, and the postoperative number of visits and days to release of care.

Seventy patients in the Clareon group and 68 in the LAL group completed the study. At three months, Clareon was non-inferior to LAL for all binocular corrected and uncorrected visual acuities except UNVA. Spectacle independence for distance, intermediate, and near were 91% (64/70), 87% (61/70), and 33% (23/70) (Clareon) vs 93% (63/68), 94% (64/68), and 43% (29/68) (LAL). Routine care release took 31.7 ± 13.0 days (Clareon) vs 53.9 ± 17.5 days (LAL) (p < 0.001). Both groups had high refractive accuracy at 3 months, however, outcomes with Clareon remained stable from 1 to 3 months, while LAL improved with UV treatment.

Results of this study suggest similarly good refractive and visual outcomes for both Clareon monofocal/toric and LAL when both are targeting same mini-monovision.