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Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

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Related Experiment Video

Updated: Jul 15, 2026

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic
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Serum Electrolyte Changes in Foals Receiving Rhodococcus equi-Specific Hyperimmune Plasma.

Diego S Larriva1, Luis G Arroyo2, Brandon N Lillie3

  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.

Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001)
|July 14, 2026
PubMed
Summary

Rhodococcus equi-specific hyperimmune plasma (Re-HIP) increases serum electrolytes and proteins in foals. While generally safe for healthy foals, Re-HIP may pose risks for critically ill neonates.

Keywords:
electrolytesequineplasma

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Area of Science:

  • Veterinary Medicine
  • Neonatal Equine Health
  • Immunology

Background:

  • Rhodococcus equi-specific hyperimmune plasma (Re-HIP) is used to prevent pneumonia in foals.
  • Frozen plasma products (FPPs) contain electrolytes that may exceed neonatal foal plasma concentrations.
  • Understanding FPP effects on neonatal homeostasis is crucial due to their use in treating failure of passive transfer and sepsis.

Purpose of the Study:

  • To evaluate the effects of Re-HIP administration on serum electrolyte and protein concentrations in healthy neonatal foals.
  • To assess the impact of Re-HIP on sodium (Na+), chloride (Cl-), potassium (K+), albumin, and globulin levels.

Main Methods:

  • Administration of Re-HIP to healthy neonatal foals.
  • Measurement of serum Na+, Cl-, K+, albumin, and globulin concentrations post-administration.

Main Results:

  • Re-HIP exhibited higher Na+ concentration compared to normal plasma.
  • Foals receiving Re-HIP showed increased serum concentrations of Na+, Cl-, albumin, and globulin.

Conclusions:

  • Serum electrolyte changes from Re-HIP were likely not clinically significant in healthy foals.
  • Hypernatremic plasma administration could worsen electrolyte imbalances in septic or dehydrated foals.
  • Caution and monitoring are advised when administering FPPs to critically ill foals.