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Published on: August 21, 2021
An Insect Chitosan/Konjac Glucomannan Multifunctional Photo-Cross-Linking Hydrogel Loaded with a Baicalin
Yingxi Li1, Xiao Zhou1, Ying Wang1
1Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, Key Laboratory of Standardization of Chinese Medicine (Chengdu University of Traditional Chinese Medicine), Ministry of Education, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu611137, China.
This study presents a new hydrogel dressing for diabetic wounds infected with MRSA. The advanced material accelerates healing, reduces inflammation, and fights infection, offering a promising treatment option.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Diabetic wounds present complex challenges, including high infection risk and inflammation, which traditional dressings fail to address.
- Developing multifunctional wound dressings is crucial for effective clinical management of these complex wounds.
Purpose of the Study:
- To develop a dual-cross-linked photopolymerizable hydrogel (Q/O/Z@B/UV) for treating Methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wounds.
- To evaluate the hydrogel's properties, including mechanical strength, biocompatibility, degradability, and biological activities.
Main Methods:
- Fabrication of a hydrogel integrating quaternized insect chitosan, methacrylate-oxidized konjac glucomannan, and a baicalin-modified zeolitic imidazolate framework-8 nanosystem.
- Assessment of hydrogel properties and in vivo evaluation using a MRSA-infected diabetic rat full-thickness skin defect model.
Main Results:
- The Q/O/Z@B/UV hydrogel demonstrated excellent mechanical properties, biocompatibility, degradability, hemostasis, and antimicrobial activity.
- The integrated Z@B system enhanced antibacterial, antioxidant, and anti-inflammatory effects, promoting cell proliferation and differentiation.
- In vivo studies showed accelerated wound closure, increased collagen deposition, suppressed inflammation, and enhanced angiogenesis in treated diabetic rat models.
Conclusions:
- The multifunctional Q/O/Z@B/UV hydrogel shows significant potential for treating MRSA-infected diabetic wounds.
- This advanced hydrogel dressing offers a promising therapeutic strategy by addressing multiple aspects of complex wound healing.