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Related Experiment Video

Updated: Jul 15, 2026

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
06:25

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

Unformed Conus Medullaris in Children With Spinal Lipoma Is a Risk Factor Requiring Clean Intermittent

Shinako Takeda1,2, Naoki Kawamorita2, Tsubasa Shironomae1

  • 1Department of Urology, Miyagi Children's Hospital, Sendai, Japan.

Neurourology and Urodynamics
|July 14, 2026
PubMed
Summary

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Children with spinal lipoma requiring clean intermittent catheterization (CIC) often have an unformed conus medullaris. Early identification of risk factors like detrusor overactivity and detrusor-sphincter dyssynergia is crucial for managing neurogenic lower urinary tract dysfunction.

Area of Science:

  • Pediatric Urology
  • Neuroscience
  • Developmental Biology

Background:

  • Spina bifida is a leading cause of neurogenic lower urinary tract dysfunction (NLUTD) in children.
  • Spinal lipoma, a type of spina bifida occulta, presents unpredictable outcomes and can delay urinary management.
  • Clean intermittent catheterization (CIC) significantly impacts the quality of life for affected children and their caregivers.

Purpose of the Study:

  • To identify risk factors associated with the need for CIC in pediatric patients with spinal lipoma.
  • To investigate predictors of NLUTD requiring CIC in this specific patient population.

Main Methods:

  • A retrospective observational study of 116 pediatric patients (≤18 years) treated between 2007 and 2022.
  • Evaluation included videourodynamics (VUDS), imaging (MRI, CT), and clinical data.
Keywords:
clean intermitted catheterizationjunctional neurulationneurogenic urinary bladder disorderspina bifida occultaurodynamics

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Last Updated: Jul 15, 2026

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
06:25

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

  • Exclusion criteria included other congenital anomalies like anorectal malformations.

    • Main Results:

    • 41% of patients required CIC, with a median introduction age of 43.7 months.
    • Unformed conus medullaris (HR 11.5), detrusor overactivity (DO) (HR 2.23), and detrusor-sphincter dyssynergia (DSD) (HR 2.34) were significant predictors for CIC requirement.
    • No filar type spinal lipomas required CIC.

    Conclusions:

    • Unformed conus medullaris is a high-risk factor for NLUTD requiring CIC in spinal lipoma patients.
    • DO and DSD on VUDS suggest congenital neural dysgenesis, linking spinal cord development abnormalities to NLUTD.
    • Close monitoring of patients with unformed conus medullaris is recommended.