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Related Experiment Video

Updated: Jul 15, 2026

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
09:44

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

Published on: January 3, 2025

Neutrophil-Mediated Inflammatory Response to Zinc Bone Implants: A Single-Cell Transcriptomic Landscape.

Mi Du1,2,3,4, Qinyang Yan5,6, Chen Zhu5,6

  • 1Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.

Advanced Healthcare Materials
|July 14, 2026
PubMed
Summary

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Zinc implants promote bone repair by altering immune cell responses. Zn-based metals modulate neutrophil and macrophage interactions, enhancing tissue regeneration compared to titanium implants.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Regenerative Medicine

Background:

  • Zinc (Zn)-based metals are promising for bone regeneration.
  • Neutrophils are key in early inflammation and resolution.
  • Mechanisms of Zn-implant-induced inflammation require further study.

Purpose of the Study:

  • Investigate neutrophil-macrophage crosstalk around Zn-based implants.
  • Compare immune responses to Zn vs. titanium (Ti) implants.
  • Elucidate Zn implant's role in immune cell modulation.

Main Methods:

  • Single-cell transcriptomic profiling in a rat femoral model.
  • Generation of a cellular atlas of the peri-implant bone marrow microenvironment.
  • Analysis of neutrophil and macrophage subset heterogeneity and crosstalk.
Keywords:
biodegradable metalsimmunomodulationsingle cell transcriptomicstitaniumzinc

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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

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Last Updated: Jul 15, 2026

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
09:44

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

Published on: January 3, 2025

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Main Results:

  • Zn implants induced distinct neutrophil subsets, including Prtn3+ Neu with enhanced tissue repair potential.
  • Zn implants reduced macrophage reactivity, promoting Hp+ Mac dominance over Ti's Apoe+ Mac.
  • Identified Lgals9-Ighm axis mediating Ifit1bl+ Neu and Eno3+ Mac interaction under Zn.

Conclusions:

  • Degradation products of Zn-based implants modulate immune cell differentiation and interactions.
  • Zn implants influence immune cell networks, impacting biological response for bone regeneration.
  • Zn-based metals offer a distinct immunomodulatory profile for bone repair applications.