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KLF11 in Extracellular Vesicles Derived from adMSCs Inhibits Colorectal Cancer via Suppressing SOAT1-Mediated

Fan Yang1, Haitao Yu1, Jian Ni1

  • 1General Surgery Fourth Ward, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang Province, P.R. China.

Molecular and Cellular Biology
|July 14, 2026
PubMed

Insights

Adipose-derived mesenchymal stem cell extracellular vesicles (adMSCs-EVs) suppress colorectal cancer (CRC) progression. Krüppel-like factor 11 (KLF11) in adMSCs-EVs inhibits cancer growth by downregulating SOAT1 and the PI3K/AKT pathway.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality.
  • Adipose-derived mesenchymal stem cells (adMSCs) and their secreted extracellular vesicles (EVs) show potential in retarding CRC progression.

Purpose of the Study:

  • To elucidate the mechanism by which adMSCs-EVs influence CRC progression.
  • To investigate the role of Krüppel-like factor 11 (KLF11) within adMSCs-EVs in CRC.

Main Methods:

  • Analysis of KLF11 expression in adMSCs-EVs.
  • In vitro and in vivo experiments using adMSCs-EVs and KLF11-depleted adMSCs-EVs (adMSCs-EVssh-KLF11).
  • Investigation of the PI3K/AKT signaling pathway and sterol o-acyltransferase 1 (SOAT1) expression.

Main Results:

  • KLF11 was upregulated in adMSCs-EVs.
  • adMSCs-EVssh-KLF11 promoted CRC cell lipogenesis, viability, proliferation, migration, invasion, and accelerated tumor growth.
  • adMSCs-EVs-derived KLF11 suppressed the PI3K/AKT pathway by repressing SOAT1 transcription.
  • SOAT1 knockdown mimicked the pro-tumorigenic effects of adMSCs-EVssh-KLF11.

Conclusions:

  • KLF11 delivered by adMSCs-EVs inhibits CRC progression.
  • The mechanism involves the inactivation of the PI3K/AKT signaling pathway via transcriptional downregulation of SOAT1.
  • This process suppresses lipogenesis and malignant behaviors in colorectal cancer cells.
Keywords:
Colorectal cancerKLF11adipose-derived mesenchymal stem cellsextracellular vesicleslipogenesis

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