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Updated: Jul 15, 2026

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Quantifying Lateral Pulsation in Retinal Vessels Within the Optic Disc.

Aleksandar Vukmirovic^1,2, William H Morgan^1,2, Danail Obreschkow^2,3

¹Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley (Perth), Western Australia.

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|July 14, 2026

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Researchers developed a new method to quantify lateral pulsation in the optic disc, offering insights into cardiovascular health. This technique complements existing methods for axial pulsation measurement.

Area of Science:

Ophthalmology
Biomedical Engineering
Cardiovascular Research

Background:

The retina offers a noninvasive view of optic disc vascular pulsations, reflecting vascular stiffness, hemodynamics, and ocular pressure.
Pulsation analysis aids in assessing ocular and systemic cardiovascular health.
Existing methods like photoplethysmography (PPG) can quantify axial pulsation, but lateral pulsation remains unquantified.

Purpose of the Study:

To present a novel method for quantifying lateral pulsation in the optic disc.
To enable a more comprehensive assessment of vascular dynamics within the optic disc.

Main Methods:

Acquired optic disc video over multiple cardiac cycles.
Aligned and warped frames to a common space, then averaged to create a template for vessel segmentation.

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Computed sub-pixel vessel wall displacements using inverse warps and harmonic regression models to compare with axial pulsation from PPG.

Main Results:

The developed method successfully quantified lateral pulsation in optic disc veins of healthy subjects.
Lateral pulse waves were largely in phase with axial pulse waves, with minor phase differences (4.4%-9.2% of cardiac cycle).
Observed asymmetric lateral wall displacements ranged from 6.33 to 25.2 µm.

Conclusions:

The presented method is effective for quantifying lateral pulsation within the optic disc.
This technique shows proof-of-concept feasibility and potential for future biomarker development in cardiovascular health assessment.