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Differences in Posterior Ocular Morphology Following Red Light Therapy Versus 0.01% Atropine for Myopia Control: A
Ziwei Zhao1,2, Yue Wu1,2, Fan Song1,2
1School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, People's Republic of China.
Investigative Ophthalmology & Visual Science
|July 14, 2026
Summary
Repeated low-level red-light (RLRL) therapy demonstrated greater macular flattening than low-dose atropine (LDA) in myopic children over 12 months. RLRL also induced more region-specific changes in macular outward scleral height.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Pediatric Medicine
Background:
- Myopia is a growing global health concern, particularly in children.
- Current treatments aim to slow myopia progression and manage associated ocular changes.
- Understanding the impact of different treatments on macular morphology is crucial for long-term eye health.
Purpose of the Study:
- To compare longitudinal changes in 3D macular morphology between repeated low-level red-light (RLRL) therapy and 0.01% low-dose atropine (LDA) in myopic children.
- To assess differences in macular curvature, outward scleral height, and asymmetry indices between the two treatment groups.
Main Methods:
- Secondary analysis of a randomized controlled trial involving 50 myopic children (aged 7-15 years).
- Treatments included RLRL therapy or 0.01% atropine eye drops.
- Spectral-domain optical coherence tomography (OCT) was used at baseline and 12 months to quantify macular curvature (MC), macular outward scleral height (MOSH), and asymmetry indices.
Main Results:
- RLRL therapy resulted in significantly greater macular flattening across all regions compared to LDA at 12 months.
- MOSH showed distinct superior and inferior changes in the RLRL group, unlike the minimal changes with LDA.
- Macular curvature asymmetry indices increased significantly more with RLRL treatment.
Conclusions:
- RLRL therapy demonstrated broader macular flattening and more region-specific MOSH changes compared to 0.01% atropine over 12 months.
- Further research is needed to elucidate the underlying mechanisms and the role of myopic progression in these observed morphological differences.
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