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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Engineering an injectable and tunable hydrogel as a potential vitreous substitute.

Ting Wang¹, Lang Qin², Yuanyuan Ding²

¹Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan, China. zhangmingscu0905@163.com.

Journal of Materials Chemistry. B

|July 14, 2026

Summary

Researchers developed an injectable hydrogel using polyethylene glycol (PEG) and hyaluronic acid (HA) to serve as a stable intraocular endotamponade. This new vitreous substitute demonstrates promising in situ gelation and biocompatibility for treating blindness-causing retinal conditions.

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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

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Published on: September 29, 2017

Area of Science:

Biomaterials Science
Ophthalmology
Polymer Chemistry

Background:

Intraocular endotamponades are crucial for treating retinal detachment and proliferative diabetic retinopathy.
Current endotamponades face challenges with dispersion and fragmentation, limiting clinical use.
Developing injectable materials with controlled in situ gelation is essential for vitreous substitution.

Purpose of the Study:

To create an injectable hydrogel mimicking human vitreous properties for intraocular applications.
To develop a stable endotamponade with tunable viscosity and in situ gelation.
To evaluate the in vivo performance and biocompatibility of the novel hydrogel.

Main Methods:

Synthesized a polyethylene glycol (PEG) hydrogel incorporating high-molecular-weight hyaluronic acid (HA).
Utilized covalent crosslinking between eight-arm PEG-thiol (8sPEG-SH) and eight-arm PEG-maleimide (8sPEG-MAL).
Characterized hydrogel properties (storage modulus, gelation time, transparency, surface tension, swelling ratio) and performed in vivo studies in rabbit eyes.

Main Results:

The PEG-HA hydrogel demonstrated a storage modulus of 15 Pa and tunable in situ gelation in approximately 3 minutes.
Achieved good optical transparency, appropriate surface tension, and a low swelling ratio.
In vivo studies confirmed smooth injectability and stable structure formation within the vitreous cavity in rabbit eyes.

Conclusions:

The developed tunable PEG hydrogel system offers a promising new strategy for vitreous substitutes.
Controllable in situ gelation via a double-chamber syringe enhances clinical applicability.
The hydrogel exhibits favorable intraocular biocompatibility and practical operability for ophthalmic applications.