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Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions
Published on: November 12, 2017
Controlling scissors during DNA repair of UV light-induced damage
Patricia L Opresko1,2, Orlando D Schärer1,2
1Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
None:
Nucleotide excision repair is essential for genome stability; however, enzymatic scissors that remove damage must be tightly regulated to prevent erroneous DNA cleavage. In this issue, Muniesa-Vargas et al. (https://doi.org/10.1083/jcb.202602121) used live-cell imaging to uncover how cutting DNA by XPG endonuclease is controlled during repair.
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