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Related Experiment Video

Updated: Jul 16, 2026

A High-Throughput In Situ Method for Estimation of Hepatocyte Nuclear Ploidy in Mice
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A High-Throughput In Situ Method for Estimation of Hepatocyte Nuclear Ploidy in Mice

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Free-Structure based Efficient NIR-II FMT: A Solution for Human Hepatocellular Carcinoma Detection.

Ziyu Pei, Yifei Du, Chunzhao Li

    IEEE Transactions on Bio-Medical Engineering
    |July 14, 2026
    PubMed
    Summary

    This study introduces a new fluorescence molecular tomography (FMT) system for precise intraoperative hepatocellular carcinoma (HCC) detection. The innovative approach enhances 3D surgical navigation and accelerates clinical translation for better cancer treatment.

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    Area of Science:

    • Medical Imaging
    • Biomedical Engineering
    • Oncology

    Background:

    • Current intraoperative hepatocellular carcinoma (HCC) detection methods lack precision in tumor localization and 3D morphology.
    • Existing fluorescence molecular tomography (FMT) is limited to preclinical research due to challenges in dynamic anatomical acquisition, optical parameter accuracy, and reconstruction algorithms.

    Purpose of the Study:

    • To develop a novel free-structure based efficient near-infrared-II (NIR-II) FMT solution for precise intraoperative HCC detection and surgical guidance.
    • To overcome limitations of current FMT techniques and facilitate clinical translation.

    Main Methods:

    • Implemented a Free-Structural Multimodal Fusion Imaging (FSMFI) system with a 3D scanner for dynamic intraoperative anatomy acquisition.
    • Developed accurate human HCC optical parameters for precise light transport modeling.

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    A High-Throughput In Situ Method for Estimation of Hepatocyte Nuclear Ploidy in Mice
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  • Utilized an Adaptive Gaussian Weighted Smoothing (AGWS) method with an energy-intensity difference prior for stable and accurate source reconstruction.

    • Main Results:

    • Simulation experiments validated the accuracy of the AGWS reconstruction method.
    • Porcine liver phantom experiments confirmed the overall efficacy of the proposed FMT solution.
    • Ex vivo and in vivo human HCC experiments demonstrated significant clinical efficacy and translational potential.

    Conclusions:

    • The developed free-structure based efficient NIR-II FMT solution represents a breakthrough in intraoperative FMT reconstruction.
    • This advancement overcomes preoperative structural constraints, enhances 3D surgical navigation, and accelerates FMT's clinical translation for HCC.
    • The study paves the way for improved surgical guidance and outcomes in liver cancer treatment.