Recent progress in nanoparticulate lipid-based co-delivery systems containing gene-based cargoes for the treatment of...

Lipid-based nanoparticulate systems provide a versatile and multifaceted platform that directly addresses critical drug delivery challenges. By encapsulating a diverse spectrum of therapeutic agents, these systems significantly enhance biocompatibility, improve bioavailability, and ensure superior stability, thereby maximizing therapeutic potential. These systems can act as non-viral vectors for successful delivery of gene-based molecules to required sites and provide the desired therapeutic effects. Conversely, the implementation of a co-delivery strategy for both oncological and non-oncological conditions holds significant promise for substantially improving clinical outcomes, and one of the main platforms for achieving synergistic effects is employing lipid-based systems. This article aims to review the recent progress in co-delivery approaches by employing lipid-based delivery systems containing gene-based cargoes.