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Sexual Development and Ascospore Discharge in Fusarium graminearum
Published on: March 29, 2012
Nigroepocins A-D: Antifungal Polyketides from Nigrospora sp. SN56127 with Activity against Fusarium graminearum
Shijun Zhong1, Jiajun Chen1, Huiyuan Yu1
1College of Plant Protection, Shenyang Agricultural University, Shenyang110866, People's Republic of China.
Abstract:
Nigroepocins A-D (1-4), along with one known compound clavatol (5), were isolated from the fermentation broth of Nigrospora sp. SN56127. Their structures, including absolute configurations, were determined by NMR, MS, and single-crystal X-ray diffraction analyses. Each of the four compounds (1-4) possesses a three-membered epoxy ring, which is rare in other compounds isolated from Nigrospora. All compounds (1-5) were evaluated for their antifungal activities against Fusarium graminearum, and nigroepocin A (1) exhibited inhibition with EC50 values of 110 and 23.1 μM against mycelial growth and conidial germination, respectively.
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