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Updated: Jul 16, 2026
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Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
Published on: August 19, 2025
Is Breast Conserving Surgery Oncologically Safe for Patients With Multiple Ipsilateral Breast Cancers? A Systematic
Reem Althawadi1, Reem Y Albuainain1, Noora F Ali1
1General Surgery, Salmaniya Medical Complex, Government Hospitals, Manama, Bahrain.
Clinical Breast Cancer
|July 14, 2026
Summary
Breast conserving surgery (BCS) offers comparable oncological outcomes to mastectomy for multiple ipsilateral breast cancers (MIBC). BCS may improve overall survival, but caution is advised due to study limitations.
Area of Science:
- Oncology
- Surgical Oncology
- Breast Cancer Research
Background:
- Increasing incidence of multiple ipsilateral breast cancers (MIBC), encompassing multifocal and multicentric tumors.
- Breast conserving surgery (BCS) is standard for early breast cancer but controversial for MIBC due to safety concerns.
Purpose of the Study:
- To compare oncological outcomes between BCS and mastectomy in patients diagnosed with MIBC.
Main Methods:
- Systematic literature search for comparative studies.
- Meta-analysis using Mantel-Haenszel method to assess local recurrence (LR), locoregional recurrence (LRR), distant recurrence (DR), disease-free survival (DFS), and overall survival (OS).
Main Results:
- Analysis of 17 studies with 29,711 patients (9587 BCS, 20124 mastectomy).
- No significant differences in LR, LRR, DR, or DFS between BCS and mastectomy.
- BCS showed improved overall survival (OS), though not consistently in all analyses.
Conclusions:
- BCS can achieve comparable oncological outcomes to mastectomy in MIBC patients with negative margins and adjuvant radiotherapy.
- Findings require cautious interpretation due to study heterogeneity and potential selection bias.
