Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Waveguide-assisted plasmonic nanoparticle sensor using light scattering-based optical interrogation.

Devesh Barshilia¹, Akhil Chandrakanth Chandrakanth Komaram², Lai-Kwan Chau²

¹AIM-HI, National Chung Cheng University, No.168, Sec. 1, University Rd, Mechanical Factory 307 National Chung Cheng University, Chiayi County, Chiayi County, Township / District, 621301, Taiwan.

|July 14, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synthesis of Carboxymethyl Dextran-Coated Gold Nanoparticles as Stable and Storable Optical Labels for Ultrasensitive Plasmonic Nanoparticle-Linked Sorbent Assay.

Sensors (Basel, Switzerland)·2025

Same author

Practical and Compact Guided Mode Resonance Sensing System for Highly Sensitive Real-Time Detection.

Sensors (Basel, Switzerland)·2025

Same author

Integration of CRISPR/Cas12a and a Fiber Optic Particle Plasmon Resonance Sensor for Single Nucleotide Polymorphism Detection in an Aldehyde Dehydrogenase 2 Gene.

ACS sensors·2025

Same author

Waveguide-Enhanced Nanoplasmonic Biosensor for Ultrasensitive and Rapid DNA Detection.

Micromachines·2024

Same author

Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide.

Sensors (Basel, Switzerland)·2024

Same author

Noninvasive Prenatal Genetic Screening of Cell-Free Fetal DNA for Early Prediction of β-Thalassemia Using Fiber Optic Nanogold-Linked Sorbent Assay.

ACS sensors·2024

This study introduces a novel nanoplasmonic sensing method using scattered light for label-free biomolecule detection. The technique offers high sensitivity and resolution for applications in diagnostics and environmental monitoring.

Area of Science:

Nanophotonics and Plasmonics
Biosensing Technologies
Optical Metrology

Background:

Localized Surface Plasmon Resonance (LSPR) biosensing enables label-free, real-time detection of biomolecular interactions.
Conventional LSPR methods often rely on transmission or spectral-shift measurements, which can be complex.
There is a need for simplified, high-contrast detection mechanisms in nanoplasmonic sensing.

Purpose of the Study:

To propose and demonstrate a slab waveguide-enhanced scattering-based nanoplasmonic sensing approach.
To utilize gold nanoparticles (AuNPs) for refractive index sensing and biomolecule detection via scattered light intensity.
To offer a high-contrast, simplified detection mechanism compared to traditional methods.

Main Methods:

Development of a waveguide-integrated nanoplasmonic sensor utilizing gold nanoparticles (AuNPs).

Keywords:

Light scattering Localised surface plasmon resonance Real-time sensing Waveguide sensor

More Related Videos

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Related Experiment Videos

Last Updated: Jul 16, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Detection mechanism based on monitoring variations in scattered light intensity, governed by plasmonic scattering.

Experimental validation using refractive index measurements and biosensing of immunoglobulin G (IgG).

Main Results:

Demonstrated a clear, linear response of normalized scattered intensity to refractive index variations.
Achieved high sensitivity (1.60 RIU⁻¹) and resolution (6.21×10⁻⁵ RIU) for refractive index sensing.
Successfully detected immunoglobulin G with a limit of detection of 3.26 ng mL⁻¹ (21.7 pM) and excellent linearity (R² = 0.99).

Conclusions:

The slab waveguide-enhanced scattering-based nanoplasmonic sensing platform provides a high-performance, simplified detection mechanism.
The platform exhibits superior sensitivity and resolution compared to absorption-based methods.
This approach is suitable for compact, cost-efficient solutions in biomedical diagnostics, environmental analysis, and point-of-care testing.