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Task optimization and ontogenetic profile of the object-in-Place task in mice.

Mehreen Inayat¹, Arely Cruz-Sanchez², Kathleen LaDouceur¹

¹University of Toronto Scarborough, Department of Psychology, Toronto, Ontario M1C1A4, Canada.

Neurobiology of Learning and Memory

|July 14, 2026

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Mice can learn object-in-place associations, crucial for spatial memory. This study validates object-in-place tasks in mice, establishing guidelines for future spatial memory research.

Area of Science:

Neuroscience
Behavioral Neuroscience
Animal Cognition

Background:

Spatial memory, including object-place associations, is vital for animal survival and exploration.
Object-in-place (OiP) tasks are standard for assessing spatial memory in rats, but less established in mice.
Mice are increasingly important models in neuroscience, necessitating robust behavioral assays.

Purpose of the Study:

To adapt and validate spontaneous object-in-place (OiP) preference tasks for mice.
To compare OiP task performance across different mouse strains and experimental designs.
To determine the developmental emergence of OiP in a specific mouse strain.

Main Methods:

Tested three spontaneous OiP preference task designs in adult C57/129/6J and C57BL/6J mice.

Keywords:

Ontogeny Recognition memory Spatial processing

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Evaluated performance in two-object and four-object OiP tasks with varying retention intervals.

Assessed the ontogeny of the two-object OiP task in C57/129/6J mice from postnatal day 25 to 28.

Main Results:

C57BL/6J mice, but not C57/129/6J mice, showed a preference in the four-object OiP task.
Both mouse strains successfully performed the two-object OiP task with 5-minute and 1-hour retention intervals.
Two-object OiP preference emerged in C57/129/6J mice between postnatal days 25 and 28.

Conclusions:

Established effective object-in-place task designs for assessing spatial memory in mice.
Provided strain-specific performance data and developmental timelines for OiP tasks in mice.
Expanded the behavioral toolkit for spatial memory research using mice as a model organism.