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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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Tail-to-side-chain cyclization stabilizes proteins on thermoresponsive ELP-based nanoparticles

Masayasu Mie1, Kai Fujiwara1, Makoto Ichikawa1

  • 1Department of Life Science and Technology, School of Life Science and Technology, Institute of Science Tokyo, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.

Journal of Biotechnology
|July 14, 2026
PubMed
Summary

Genetically encoded cyclization enhances thermal stability of heat-labile proteins within thermoresponsive nanoparticle assemblies. This method protects proteins of interest (POIs) during self-assembly, improving activity retention at elevated temperatures.

Keywords:
Elastin-like polypeptideProtein NanoparticleProtein cyclizationSnoopTag/SnoopCatcher

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