Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Optimal Arousal Theory01:23

Optimal Arousal Theory

The optimal arousal theory suggests that performance is maximized when an individual experiences a moderate level of arousal. This theory is closely tied to the Yerkes-Dodson law, which illustrates an inverted U-shaped relationship between arousal and performance. The law, formulated by psychologists Robert Yerkes and John Dodson, implies an ideal arousal level for optimal performance, and deviations from this level can lead to declines in effectiveness.
Inverted U-Shaped Performance Curve
The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Disrupted Higher-Order Topology in OCD Brain Networks Revealed by Hodge Laplacian - an ENIGMA Study.

bioRxiv : the preprint server for biology·2026
Same author

Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.

Molecular psychiatry·2026
Same author

Sensorimotor circuit connectivity as a candidate biomarker for responsiveness to sertraline in obsessive-compulsive disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Regional Cerebellar Volumetrics in Obsessive-Compulsive Disorder: An ENIGMA-OCD Study.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

The effects of moderate-dose statin therapy on intracranial plaques with mild to moderate stenosis: a high-resolution MR vessel wall imaging study.

European radiology·2026

Related Experiment Video

Updated: Jul 16, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Altered Resting-State Co-Activation Patterns in Obsessive-Compulsive Disorder.

Yange Chang1, Hanyang Ruan1, Kathrin Koch1

  • 1Department of Neuroradiology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Neuroimage
|July 14, 2026
PubMed
Summary

Obsessive-compulsive disorder (OCD) is linked to altered brain network dynamics. Patients with OCD exhibit reduced flexibility in switching between brain states, staying longer in specific configurations.

Keywords:
brain-state dynamicsco-activation patternobsessive-compulsive disorderresting-state fMRI

More Related Videos

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
11:17

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

Related Experiment Videos

Last Updated: Jul 16, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
11:17

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Obsessive-compulsive disorder (OCD) is associated with abnormal large-scale brain network dynamics.
  • Transient whole-brain co-activation states in OCD are not well understood.
  • This study investigates alterations in whole-brain co-activation pattern (CAP) dynamics in OCD.

Purpose of the Study:

  • To characterize the dynamics of whole-brain co-activation patterns (CAPs) in individuals with OCD.
  • To compare CAP dynamics between patients with OCD and healthy controls.
  • To identify specific alterations in brain state transitions associated with OCD.

Main Methods:

  • Resting-state functional magnetic resonance imaging (rs-fMRI) data were analyzed using a CAP framework with the Brainnetome 246 atlas.
  • Co-activation pattern (CAP) states were identified using k-means clustering.
  • Temporal fraction, persistence, counts, and transition probabilities of CAP states were compared between OCD patients and healthy controls.

Main Results:

  • Three recurrent CAP states were identified, with CAP2 showing a distinct intermediate bipolar configuration involving default mode and somatomotor systems.
  • Patients with OCD demonstrated increased temporal fraction, persistence, and self-transition probability of CAP2 compared to controls.
  • OCD patients exhibited reduced counts and decreased transition probabilities from CAP2 to other states (CAP1 and CAP3).

Conclusions:

  • Obsessive-compulsive disorder is characterized by altered brain network dynamics, specifically reduced switching flexibility.
  • Individuals with OCD show an increased tendency to remain in a particular brain state configuration over time.
  • These findings highlight the role of aberrant brain state dynamics in the pathophysiology of OCD.