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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...

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Related Experiment Video

Updated: Jul 16, 2026

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
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Magnetically Compatible and Fiberless fNIRS Enables Simultaneous Multimodal Imaging with Optically Pumped

Rui Yang1, Xingyu Ru1, Jingqi Song1

  • 1Laboratory for Medical Physics and Engineering, School of Physics, Peking University, Beijing, China; Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; National Biomedical Imaging Center, Peking University, Beijing, China.

Neuroimage
|July 14, 2026
PubMed
Summary

We developed a magnetically compatible fiberless functional near-infrared spectroscopy (fNIRS) system for seamless integration with optically pumped magnetometer (OPM) magnetoencephalography (MEG). This breakthrough enables robust multimodal neuroimaging for studying brain function and connectivity.

Keywords:
fiberless fNIRSmagnetic compatibilitymagnetoencephalography (MEG)multimodal imagingneurovascular couplingoptically pumped magnetometer

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Simultaneous functional near-infrared spectroscopy (fNIRS) and magnetoencephalography (MEG) offer complementary insights into neurovascular coupling.
  • Previous implementations used fiber-based fNIRS, which has limitations.
  • Fiberless fNIRS is lighter and more flexible but faces magnetic compatibility challenges with MEG.

Purpose of the Study:

  • To develop a magnetically compatible, fiberless fNIRS system for integration with optically pumped magnetometer (OPM) MEG.
  • To overcome magnetic interference issues for robust multimodal neuroimaging.
  • To enable flexible and non-invasive studies of neurovascular coupling.

Main Methods:

  • Designed magnetically compatible source/detector optodes for fiberless fNIRS.
  • Implemented a multipole moment flexible printed circuit design to suppress magnetic fields.
  • Tested the system's magnetic compatibility and impact on OPM sensitivity.
  • Demonstrated simultaneous fiberless fNIRS and OPM-MEG acquisition in a somatosensory paradigm.

Main Results:

  • The developed optodes and cables generated minimal magnetic fields (<1 nT at ~1 cm), ensuring no measurable impact on OPM sensitivity.
  • Achieved >1000-fold suppression of driving-current-induced magnetic fields.
  • Successfully captured concurrent hemodynamic (fNIRS) and evoked magnetic (MEG) responses.
  • Demonstrated the feasibility and robustness of the integrated fiberless fNIRS and OPM-MEG system.

Conclusions:

  • This work presents a novel, magnetically compatible fiberless fNIRS system integrated with OPM-MEG.
  • It addresses a key barrier, enabling flexible and non-invasive multimodal neuroimaging.
  • Paves the way for advanced neurovascular coupling studies, wearable neuroimaging, and brain-computer interfaces.