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Published on: August 23, 2019
Dietary Polysaccharides Modulate Interactions between Bacteroides and the Gut Microbiota: Gene-Level Mechanisms and
Yueyi Zhang1, Xin Song1, Lianzhong Ai1,2
1School of Health Science and Engineering, Shanghai Engineering Research Center of Food Microbiology, University of Shanghai for Science and Technology, Shanghai200093, China.
None:
Bacteroides is a major gut genus involved in polysaccharide uptake and degradation, yet the gene-level mechanisms by which dietary polysaccharides modulate interactions between Bacteroides and other gut microbes remain insufficiently integrated. This review summarizes dietary-polysaccharide-driven Bacteroides interactions from the perspectives of PULs, CAZymes, released oligosaccharides, fermentation products, and GEM-based community simulation. Emphasis is placed on how PUL-CAZyme repertoires shape substrate specificity, metabolite exchange, cross-feeding, competition, commensalism, and mutualism under different glycan conditions. The review further discusses the application of GEMs to simulate Bacteroides-centered communities, including reconstruction tool selection, static and dynamic modeling frameworks, and current limitations in representing polysaccharide structure and stepwise degradation. These advances provide a framework for linking dietary polysaccharide chemistry, microbial gene functions, community metabolism, and gut health-related outcomes.
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