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Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...

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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Self-heating-induced blocking in nanopores enables neuromorphic ionic computing.

Qinyang Fan1,2, Changhui Xu1,2, Wei Liu1,3

  • 1Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, Southeast University, Nanjing, China.

Nature Communications
|July 14, 2026
PubMed
Summary

Researchers developed a novel self-heating-induced blocking memristor (SIBM) for neuromorphic computing. This fluidic memristor utilizes thermal precipitation for memory, enabling threshold switching and negative differential resistance for advanced brain-inspired computing.

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Area of Science:

  • Neuromorphic Engineering
  • Materials Science
  • Ionic Devices

Background:

  • The brain's ionic processing inspires neuromorphic systems.
  • Fluidic memristors offer a promising platform for mimicking brain functions.
  • Exploring new memristive materials and switching mechanisms is crucial for advancing neuromorphic computing.

Purpose of the Study:

  • To introduce a novel self-heating-induced blocking memristor (SIBM).
  • To investigate thermally triggered reversible precipitation as a memristive switching mechanism.
  • To demonstrate neuromorphic functionalities using fluidic memristor arrays.

Main Methods:

  • Fabrication of a self-heating-induced blocking memristor (SIBM).
  • Characterization of resistive switching behavior under periodic voltage stimulation.
  • Experimental validation of a fluidic memristor array for memory operations.

Main Results:

  • The SIBM exhibits threshold-type unipolar resistive switching.
  • A distinct negative differential resistance (NDR) phenomenon was observed.
  • Demonstrated various neuromorphic functions and successful repeated memory operations in a fluidic array.

Conclusions:

  • SIBMs offer a new pathway for ionic neuromorphic devices.
  • Thermally triggered precipitation is a viable memristive switching mechanism.
  • The developed fluidic memristor array shows potential for next-generation neuromorphic systems.