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Updated: Jul 16, 2026

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
Published on: May 4, 2018
Rational dsRNA design, scalable production and nanodelivery to enhance spray-induced gene silencing
Guoning Zhu1, Chao Xu2,3, Tao Zhang4
1State Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.
None:
Spray-induced gene silencing (SIGS) provides a sustainable, highly targeted alternative to chemical pesticides. This review summarizes recent advances in dsRNA technology through a design-to-delivery framework. Key focuses include bioinformatics-driven multi-target dsRNA design for improved stability and efficacy, cost-effective microbial and cell-free synthesis platforms for scalable production, and nanocarriers that protect dsRNA from degradation while enhancing delivery. Integrating rational design, efficient production, and precision nanodelivery will accelerate SIGS from laboratory concept to practical, eco-friendly tool for global crop protection and sustainable agriculture.
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