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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

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Related Experiment Video

Updated: Jul 16, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

Prediction model for aortic dissection, aortic aneurysm, and peripheral artery disease.

Yuta Suzuki1,2, Hidehiro Kaneko3,4, Akira Okada5

  • 1Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|July 14, 2026
PubMed
Summary

Validated risk prediction models for aortic dissection (AD), aortic aneurysm (AA), and peripheral artery disease (PAD) were developed using routine health check-up data. These models can aid in early diagnosis and intervention for these life-threatening vascular conditions.

Keywords:
Aortic aneurysmAortic dissectionImplementation hypertensionPeripheral artery diseaseRisk prediction model

Related Experiment Videos

Last Updated: Jul 16, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

Area of Science:

  • Cardiovascular Medicine
  • Epidemiology
  • Biostatistics

Background:

  • Aortic dissection (AD), aortic aneurysm (AA), and peripheral artery disease (PAD) are significant causes of mortality.
  • Validated prediction models for these vascular conditions are currently scarce.
  • Routine health check-up data offers a potential resource for risk stratification.

Purpose of the Study:

  • To develop and validate risk prediction models for AD, AA, and PAD.
  • To utilize routine health check-up data for estimating 5-year risk of these diseases.
  • To enable earlier diagnosis and intervention for vascular diseases through risk stratification.

Main Methods:

  • Development of flexible parametric survival models using a large dataset (1,082,369 participants).
  • Random split of participants into derivation (50%) and internal validation (50%) cohorts.
  • Inclusion of variables such as age, sex, BMI, blood pressure, lipids, glucose, smoking, physical activity, and medication use.

Main Results:

  • Models demonstrated good predictive performance with Harrell's C-index: 0.781 for AD, 0.812 for AA, and 0.701 for PAD.
  • Royston D statistics indicated strong discriminative ability for all outcomes.
  • The developed models showed good calibration across the prediction ranges.

Conclusions:

  • Validated risk prediction models for AD, AA, and PAD have been successfully developed using routine health check-up data.
  • These models can facilitate risk stratification, potentially leading to earlier diagnosis and intervention.
  • External validation in diverse populations and settings is recommended to confirm generalizability.