Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Design and Performance Analysis of a Bionic Radially Gradient Irregular Bone Scaffold.

Qingyu Xu¹, Jizhe Hai², Jie Chen¹

¹School of Ecology and Environment, Xinjiang University, Urumqi 830017, China.

ACS Biomaterials Science & Engineering

|July 14, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Expression of eosinophil major basic protein and neutrophil elastase in nasal polyp tissue and secretion].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2008

Same author

[Effect of interferon-gamma on the expression of vascular endothelial growth factor C on Hep-2 laryngeal carcinoma cell lines].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2008

Same author

Effects of 18alpha-glycyrrhizin on the pharmacodynamics and pharmacokinetics of glibenclamide in alloxan-induced diabetic rats.

European journal of pharmacology·2008

Same author

[Inhibition of oxidative activity of myeloperoxidase by anti-myeloperoxidase antibodies from patients with microscopic polyangiitis].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2008

Same author

Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses.

The journal of gene medicine·2008

Same author

[Ultrasonographic findings of intussusception complicated by intestinal necrosis in children].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2008

Researchers developed novel radially graded irregular scaffolds using Voronoi tessellation for bone tissue engineering. The PG1-DG1 scaffold design demonstrated superior permeability and cell adhesion, mimicking native bone for enhanced long-bone repair.

Area of Science:

Biomaterials Science
Orthopedic Engineering
Tissue Engineering

Background:

Conventional periodic lattices lack the heterogeneity of native bone.
Existing Voronoi scaffolds are limited to homogeneous or axially graded designs.
Radially graded irregular scaffolds for long-bone repair are underexplored.

Purpose of the Study:

To develop and evaluate biomimetic radially graded irregular scaffolds for long-bone repair.
To investigate the synergistic effects of seed-point distribution and strut-diameter gradient on scaffold properties.
To optimize scaffold design for improved mechanical, mass transport, and biofunctional performance.

Main Methods:

Nine radially graded irregular scaffolds were designed using Voronoi tessellation with a target porosity of 70%.

Keywords:

Voronoi tessellation additive manufacturing bionic performance gradient scaffold mechanobiology

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

Related Experiment Videos

Last Updated: Jul 16, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

Synergistic tailoring of seed-point distribution (PG) and strut-diameter gradient (DG) was employed.

Numerical analysis and experimental validation were used to assess geometric features, mechanical properties, mass transport, and cell adhesion.

Main Results:

Scaffolds exhibited elastic moduli of 4.09-7.29 GPa and yield strengths of 75.30-271.35 MPa.
Permeabilities ranged from 1.93-2.71 × 10^-8 m², and cell adhesion rates were 2.93-9.31%.
Seed-point distribution influenced permeability and cell adhesion; strut-diameter grading affected mechanical properties and cell differentiation.

Conclusions:

The PG1-DG1 scaffold, with radially decreasing porosity, showed the highest permeability and cell adhesion.
This design offers a stress-transfer pattern consistent with native long bone.
Provides a rational design strategy for load-bearing, biomimetic bone scaffolds with balanced performance.