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Traits, Mood, and Subjective Wellbeing01:22

Traits, Mood, and Subjective Wellbeing

Subjective well-being (SWB) refers to an individual's self-evaluation of their overall life satisfaction, happiness, and fulfillment. This multifaceted construct is typically assessed by analyzing the balance of positive and negative emotions alongside perceptions of life satisfaction. Personality traits such as neuroticism and extraversion are strongly associated with variations in SWB, offering critical insights into the underlying mechanisms of emotional well-being.
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Social Relationships and Well-Being

The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...
Human Genetics01:28

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The Influence of Affect on Cognition01:29

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Related Experiment Video

Updated: Jul 16, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Epigenome-wide association study meta-analysis of wellbeing.

Meike Bartels1,2, Margot P van de Weijer1,2,3, Natalia Azcona-Granada1,2

  • 1Department of Biological Psychology, Vrije Universiteit Amsterdam, Van Der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.

Clinical Epigenetics
|July 15, 2026
PubMed
Summary

This study found no significant epigenetic markers for wellbeing in the largest epigenome-wide meta-analysis to date. Further research with larger sample sizes and consistent wellbeing measures is needed to uncover potential epigenetic links.

Related Experiment Videos

Last Updated: Jul 16, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Area of Science:

  • Epigenetics
  • Behavioral Science
  • Psychiatry

Background:

  • Wellbeing is linked to behavioral traits and life outcomes like health and employment.
  • Epigenetic patterns may differ between individuals with varying wellbeing levels.

Purpose of the Study:

  • To conduct the largest epigenome-wide association study (EWAS) meta-analysis for wellbeing.
  • To investigate if epigenetic markers predict wellbeing beyond genetic predisposition.

Main Methods:

  • Meta-analysis of whole blood DNA methylation data from 13 cohorts (N=10,757).
  • Analysis of a weighted methylation score (MS) and polygenic score (PGS) for wellbeing.
  • Comparison of DNA methylation in monozygotic twins discordant for wellbeing.

Main Results:

  • No epigenome-wide significant methylation sites were identified after adjusting for smoking and BMI.
  • A weighted methylation score (MS) showed a modest association with wellbeing, which was not significant when accounting for the polygenic score (PGS).
  • No significant within-pair DNA methylation differences were found in twins discordant for wellbeing.

Conclusions:

  • Current epigenome-wide meta-analyses lack the power to detect methylation sites associated with wellbeing.
  • Larger EWAS meta-analyses with standardized wellbeing assessments are necessary to identify epigenetic associations.