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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jul 16, 2026

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
11:11

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

Small Is Beautiful: Is ctDNA Ready for Routine Implementation in Cancer Management?

Caroline Bailleux1, Jean-Marc Ferrero1, Rym Bouriga2

  • 1Department of Medical Oncology, Antoine Lacassagne Center, University Côte d'Azur, 33 Avenue de Valombrose, 06189 Nice, France.

Cancers
|July 15, 2026
PubMed
Summary

Circulating tumor DNA (ctDNA) offers non-invasive cancer detection and monitoring. Advances in AI and standardization are key to integrating ctDNA into precision oncology for better patient outcomes.

Keywords:
NGSartificial intelligencectDNAliquid biopsiesminimal residual diseasetumor markers

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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

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Last Updated: Jul 16, 2026

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
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Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Bioinformatics

Background:

  • Circulating tumor DNA (ctDNA) is tumor-derived DNA in blood.
  • ctDNA aids in early cancer detection, resistance identification, and screening.
  • It's crucial for prognosis and guiding adaptive treatment strategies.

Purpose of the Study:

  • To highlight the clinical utility of ctDNA in cancer diagnostics.
  • To discuss the role of AI in advancing ctDNA analysis.
  • To outline requirements for ctDNA assay implementation.

Main Methods:

  • Review of current ctDNA applications in oncology.
  • Discussion of AI's role in ctDNA biomarker development.
  • Analysis of challenges for clinical integration.

Main Results:

  • ctDNA is valuable for early detection, resistance monitoring, and minimal residual disease assessment.
  • AI enhances ctDNA analysis for dynamic molecular sensing.
  • Real-time tumor evolution tracking is enabled by ctDNA.

Conclusions:

  • ctDNA is a powerful tool for precision oncology.
  • AI integration promises to transform ctDNA into a predictive biomarker.
  • Prospective validation, standardization, and regulatory approval are essential for widespread clinical adoption.