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Immunogenetic and Transcriptomic Evidence Implicating the NKG2D-MICA/MICB Axis in CALR-Mutated Myeloproliferative

Velizar Shivarov1,2, Gergana Tsvetkova3, Ilina Micheva4

  • 1Department of Experimental Research, Medical University Pleven, 5800 Pleven, Bulgaria.

Cancers
|July 15, 2026
PubMed
Summary

This study explores the link between NKG2D receptor ligands (MICA/MICB) and CALR-mutated myeloproliferative neoplasms (MPN). Specific MICA and KLRK1 gene variants were associated with increased MPN risk, suggesting an immunogenetic role.

Keywords:
KLRK1MICAMICBNKG2Dcalreticulin (CALR)immune surveillanceimmunogeneticsmyeloproliferative neoplasms

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