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Published on: December 15, 2014
Time-Dependent Diffusion MRI-Based Microstructural Mapping for Characterization of Cribriform and Intraductal
Yanchun Wei1, Shicong Yang2, Tuo Ren1
1Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Cancers
|July 15, 2026
Summary
Time-dependent diffusion MRI shows potential for identifying aggressive prostate cancer morphologies, specifically intraductal carcinoma (IDC) and cribriform (Cr) patterns. This advanced imaging technique helps characterize these adverse features before surgery.
Area of Science:
- Radiology and Oncologic Imaging
- Biomedical Engineering
- Prostate Cancer Research
Background:
- Intraductal carcinoma (IDC) and invasive cribriform (Cr) patterns are adverse prostate cancer (PCa) morphologies.
- Accurate preoperative identification of these patterns is crucial for risk stratification and treatment planning.
Purpose of the Study:
- To evaluate the feasibility of time-dependent diffusion MRI (td-dMRI)-based microstructural mapping for preoperative characterization of aggressive PCa morphologies (Cr/IDC).
Main Methods:
- Retrospective analysis of 95 PCa patients undergoing radical prostatectomy.
- td-dMRI acquisition using pulsed and oscillating gradient sequences.
- Estimation of microstructural parameters (f_in, cellularity, D_ex, d, ADC values) using a two-compartment model.
Main Results:
- Cr/IDC-positive tumors exhibited significantly higher intracellular volume fraction (f_in) and cellularity compared to Cr/IDC-negative tumors.
- Lower ADC values (ADC_DWI, ADC_0Hz, ADC_17Hz, ADC_33Hz) were observed in Cr/IDC-positive tumors.
- f_in demonstrated the highest diagnostic performance (AUC = 0.757) for differentiating Cr/IDC patterns.
Conclusions:
- td-dMRI-based microstructural mapping shows promise for preoperative characterization of aggressive Cr/IDC morphologies in prostate cancer.
- This advanced imaging approach may improve risk stratification and surgical planning for PCa patients.
