Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diagnostic accuracy of modern imaging following neoadjuvant therapy for breast cancer: a comparative analysis of ultrasound versus [18F] FDG PET/MRI in breast response assessment.

Frontiers in oncology·2026

Same author

Novel PET tracers to distinguish the nature of residual masses after the completion of chemotherapy in metastatic testicular germ cell tumours: A systematic review.

European journal of nuclear medicine and molecular imaging·2026

Same author

European Cancer Prevention Organization on cancer screening: an expert panel position paper.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)·2026

Same author

Tucatinib in patients with HER2-positive advanced/metastatic breast cancer: A systematic literature review of real-world evidence.

Breast (Edinburgh, Scotland)·2026

Same author

Pan-cancer multi-omic integration of Trop2 reveals biological determinants and translational implications for ADC therapy.

NPJ precision oncology·2026

Same author

Impact of PSMA-Based Radiopharmaceuticals on the Clinical Management of Prostate Cancer.

Cancers·2026

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing ¹⁸F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Subtype-Specific Metabolic Patterns in Staging Breast Cancer: Insights from Conventional and Parametric PET

Sara Calzolai Lettieri¹, Jelena Jandric², Lidija Antunovic²

¹Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy.

|July 15, 2026

Summary

Dynamic PET imaging with Patlak analysis reveals distinct metabolic patterns in breast cancer subtypes. These kinetic parameters (K_i and V_d) show potential for differentiating breast cancer (BC) phenotypes.

Keywords:

Luminal breast cancer Patlak imaging breast cancer dynamic PET/CT parametric imaging triple-negative breast cancer

More Related Videos

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Related Experiment Videos

Last Updated: Jul 16, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing ¹⁸F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Area of Science:

Nuclear Medicine
Radiology
Oncology

Background:

Breast cancer (BC) is a heterogeneous disease with varying aggressiveness and treatment responses.
¹⁸F-FDG PET/CT provides semi-quantitative SUV, while dynamic PET with Patlak analysis offers quantitative kinetic parameters (K_i, V_d).
Limited data exist on kinetic parameter interpretation in normal breast tissue and across BC subtypes.

Purpose of the Study:

To explore the feasibility of deriving reference ranges for non-pathological breast tissue using dynamic ¹⁸F-FDG PET.
To describe subtype-specific patterns of kinetic parameters (K_i, V_d) in breast cancer.
To investigate the potential of parametric maps for characterizing breast cancer metabolism.

Main Methods:

Dynamic ¹⁸F-FDG PET/CT was performed on six breast cancer patients (Luminal, TNBC) and six controls.
Patlak kinetic analysis generated parametric K_i and V_d maps.
Non-lesional breast tissue was analyzed for reference ranges, and lesion-level radiomics features were extracted.

Main Results:

Median K_i and V_d values were established for control whole-breast tissue.
Non-lesional breast tissue in BC patients showed concordance with control values.
Distinct metabolic gradients were observed across subtypes: Luminal B (low K_i, high V_d), Luminal A (intermediate K_i, V_d), and TNBC (high K_i, variable V_d).

Conclusions:

Parametric maps derived from dynamic PET show promise for establishing physiological kinetic ranges in breast tissue.
Observed K_i and V_d patterns may reflect metabolic differences across breast cancer phenotypes.
Further validation is required to establish clinical applicability of these kinetic parameters as imaging biomarkers.