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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Published on: January 28, 2020

Early Inflammatory Biomarkers, Ventricular Dysfunction and In-Hospital Mortality in Patients with ST-Elevation

Dan Claudiu Magureanu1,2, Maria Luiza Hiceag3,4, Camelia Bianca Rus5,6,7

  • 1Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Diagnostics (Basel, Switzerland)
|July 15, 2026
PubMed

Insights

In ST-elevation myocardial infarction (STEMI) patients treated with primary PCI, inflammatory biomarkers reflect injury severity but don't predict short-term mortality. Age, ventricular dysfunction, and residual coronary disease are key mortality predictors.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Inflammation is key in ST-elevation myocardial infarction (STEMI) pathophysiology.
  • Routine inflammatory biomarkers may predict outcomes in primary percutaneous coronary intervention (PCI) patients.

Purpose of the Study:

  • Evaluate associations between admission inflammatory biomarkers, ventricular dysfunction, and in-hospital mortality in STEMI patients undergoing primary PCI.

Main Methods:

  • Retrospective observational study of 600 STEMI patients treated with primary PCI.
  • Measured C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and C-reactive protein-to-lymphocyte ratio (CLR).
  • Used multivariable logistic regression to identify mortality predictors.

Main Results:

  • In-hospital mortality was 9.0%.
  • Reduced left ventricular ejection fraction (LVEF ≤ 40%) correlated with higher CRP and CLR.
  • Inflammatory biomarkers associated with ventricular dysfunction but did not independently predict mortality.

Conclusions:

  • Early mortality in STEMI patients post-PCI is driven by age, ventricular dysfunction, and residual coronary disease.
  • Inflammatory biomarkers indicate myocardial injury severity rather than independently predicting short-term mortality.

Keywords:
C-reactive proteinST-elevation myocardial infarctionin-hospital mortalityinflammatory biomarkersleft ventricular ejection fractionneutrophil-to-lymphocyte ratioprimary percutaneous coronary interventionventricular dysfunction

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