Early Inflammatory Biomarkers, Ventricular Dysfunction and In-Hospital Mortality in Patients with ST-Elevation...

Area of Science:

• Cardiology
• Biomarkers
• Inflammation

Background:

• Inflammation is key in ST-elevation myocardial infarction (STEMI) pathophysiology.
• Routine inflammatory biomarkers may predict outcomes in primary percutaneous coronary intervention (PCI) patients.

Purpose of the Study:

• Evaluate associations between admission inflammatory biomarkers, ventricular dysfunction, and in-hospital mortality in STEMI patients undergoing primary PCI.

Main Methods:

• Retrospective observational study of 600 STEMI patients treated with primary PCI.
• Measured C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and C-reactive protein-to-lymphocyte ratio (CLR).
• Used multivariable logistic regression to identify mortality predictors.

Main Results:

• In-hospital mortality was 9.0%.
• Reduced left ventricular ejection fraction (LVEF ≤ 40%) correlated with higher CRP and CLR.
• Inflammatory biomarkers associated with ventricular dysfunction but did not independently predict mortality.

Conclusions:

• Early mortality in STEMI patients post-PCI is driven by age, ventricular dysfunction, and residual coronary disease.
• Inflammatory biomarkers indicate myocardial injury severity rather than independently predicting short-term mortality.