Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrogen Production Dynamics During Lactulose Breath Testing in Patients with Suspected SIBO.

Journal of clinical medicine·2026
Same author

Does Resistant Starch Formed by Cooling Pasta Decrease the Postprandial Glycemic Response in Type 1 Diabetes? A Randomized Single-Blind Crossover Study.

Nutrients·2026
Same author

Small Intestinal Bacterial Overgrowth and Systemic Laboratory Parameters: A Multivariable Cross-Sectional Analysis.

Nutrients·2026
Same author

Frequency-Dependent Amplification of Head Motion in Infant Rockers: A Segmental IMU-Based Signal Analysis.

Journal of clinical medicine·2025
Same author

Knowledge of Shaken Baby Syndrome Among Polish Nurses and Midwives: A Cross-Sectional National Survey.

Children (Basel, Switzerland)·2025
Same author

Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E<sup>-/-</sup>/LDLR<sup>-/-</sup> Double-Knockout Mice.

Cellular and molecular neurobiology·2025

Related Experiment Video

Updated: Jul 16, 2026

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

Hydrogen Breath Test Dynamics Reflect Intestinal Fermentation Rather than Systemic Inflammation: A Data-Driven

Monika Waśkow1, Magdalena Tańska1, Sebastian Glowinski1,2

  • 1Institute of Health Sciences, Pomeranian University of Slupsk, 76-200 Slupsk, Poland.

Diagnostics (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

Hydrogen breath testing assesses gut fermentation but doesn't reflect systemic inflammation. This study found no link between hydrogen production and inflammatory markers, suggesting it primarily measures local gut activity.

Keywords:
SIBOgut microbiotahydrogen breath testinflammatory markersintestinal fermentationsystemic biomarkers

More Related Videos

Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction
09:19

Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction

Published on: June 1, 2022

Fast and Accurate Exhaled Breath Ammonia Measurement
06:27

Fast and Accurate Exhaled Breath Ammonia Measurement

Published on: June 11, 2014

Related Experiment Videos

Last Updated: Jul 16, 2026

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction
09:19

Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction

Published on: June 1, 2022

Fast and Accurate Exhaled Breath Ammonia Measurement
06:27

Fast and Accurate Exhaled Breath Ammonia Measurement

Published on: June 11, 2014

Area of Science:

  • Gastroenterology
  • Metabolic Health
  • Microbiome Research

Background:

  • Hydrogen breath testing (HBT) is standard for evaluating intestinal fermentation and diagnosing small intestinal bacterial overgrowth (SIBO).
  • The relationship between HBT-derived hydrogen production and systemic inflammatory or metabolic markers is not well-established.
  • This study aimed to clarify if hydrogen production dynamics correlate with systemic biomarkers.

Purpose of the Study:

  • To investigate the association between hydrogen production patterns during lactulose HBT and systemic inflammatory/metabolic markers.
  • To determine if HBT metrics can serve as indicators of systemic physiological status.

Main Methods:

  • A cross-sectional study of 162 adults undergoing lactulose HBT.
  • Hydrogen production was quantified using area under the curve (AUC), early/late responses, and cluster analysis.
  • Associations with serum 25-hydroxyvitamin D, CRP, leukocyte count, and IL-6 were analyzed using multivariable regression, adjusting for age and BMI.

Main Results:

  • Significant interindividual variability in hydrogen production was observed, with unsupervised clustering identifying distinct response groups.
  • No significant associations were found between any HBT hydrogen production metrics and systemic biomarkers (vitamin D, CRP, IL-6, leukocyte count).
  • Body Mass Index (BMI) showed consistent associations with inflammatory markers (CRP, IL-6), unlike HBT metrics.

Conclusions:

  • Data-driven analysis revealed heterogeneity in intestinal hydrogen production but no association with systemic inflammatory or metabolic markers.
  • HBT metrics appear to reflect localized intestinal fermentation rather than systemic physiological status.
  • While valuable for gastrointestinal function assessment, HBT is not supported as a marker for systemic inflammation in this cohort.