Multifunctional PVP/PEG Hydrogel Coatings Functionalized with Taxifolin for Surface Modification of Titanium-Based...

Area of Science:

• Biomaterials Science
• Surface Chemistry
• Nanotechnology

Background:

• Metallic implants require surface functionalization to improve performance and integration.
• Enhancing implant bioactivity and reducing inflammation are key challenges in biomaterials development.
• Naturally derived compounds offer potential for bioactive surface modifications.

Purpose of the Study:

• To develop multifunctional hydrogel coatings for titanium-based biomaterials.
• To incorporate taxifolin (TAX) and collagen for enhanced bioactivity and therapeutic effects.
• To evaluate the coatings' applicability on diverse titanium substrate morphologies.

Main Methods:

• Poly(vinylpyrrolidone) and polyethylene glycol hydrogels were synthesized.
• Taxifolin (TAX) was complexed with beta-cyclodextrin for controlled release.
• Coatings were applied to titanium-hydroxyapatite and titanium sheet substrates.
• Surface characterization (FTIR, SEM), degradation, release studies (UV-Vis), and cytotoxicity assays were performed.

Main Results:

• Hydrogel formation and effective surface coverage were confirmed.
• Coatings demonstrated stability in simulated physiological conditions.
• Controlled release of TAX was observed, indicating carrier potential.
• Modified surfaces exhibited low cytotoxicity and favorable preosteoblast response.

Conclusions:

• Developed hydrogel coatings offer a versatile platform for titanium biomaterial surface modification.
• The coatings show potential for improved implant performance due to bioactive features.
• Further research is needed to fully assess the biological potential and clinical applicability.