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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

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Related Experiment Video

Updated: Jul 16, 2026

Obtaining High-Quality Transcriptome Data from Cereal Seeds by a Modified Method for Gene Expression Profiling
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Published on: May 21, 2020

Genome-Wide Association Mapping and Integrated Transcriptomic-Genomic Analysis Reveal Candidate Genes for Grain

Fuge Cai1, Fujun Wang2, Shuai Nie2

  • 1Anshun Academy of Agricultural Sciences, Anshun 562100, China.

International Journal of Molecular Sciences
|July 15, 2026
PubMed
Summary

Researchers identified 19 quantitative trait loci (QTL) for rice grain transparency (GT) using genome-wide association studies (GWAS). Four stable QTLs were found, with two co-localizing with known grain shape genes, offering insights into rice quality improvement.

Keywords:
candidate genegenome-wide association studygrain transparencyquantitative trait loci (QTL)rice

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Area of Science:

  • Plant Genetics
  • Molecular Biology
  • Agricultural Science

Background:

  • Grain transparency (GT) significantly impacts rice appearance quality and consumer acceptance.
  • The genetic underpinnings of rice GT are not well understood, limiting targeted breeding efforts.

Purpose of the Study:

  • To identify genetic loci associated with grain transparency in rice.
  • To uncover candidate genes for improving rice appearance quality through genetic analysis.

Main Methods:

  • Genome-wide association study (GWAS) on 450 rice accessions across two environments.
  • Linkage disequilibrium decay analysis and integrative transcriptomic and genomic analyses.
  • Haplotype analysis to associate gene variants with GT variation.

Main Results:

  • Nineteen quantitative trait loci (QTL) for GT were identified across rice chromosomes.
  • Four stable QTLs were consistently detected, with two co-localizing with known grain shape genes (GS3 and GW5).
  • Two novel candidate genes, OsFbx142 and OsSUBSrP1, were identified for the stable QTL qGT-4b, with specific haplotypes linked to GT variation.

Conclusions:

  • This study provides significant genetic insights into the regulation of rice grain transparency.
  • Identified QTLs and candidate genes offer valuable resources for marker-assisted selection and breeding programs aimed at enhancing rice appearance quality.