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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
Published on: August 29, 2018
Epigenetic Functions of SMYD5 and Its Role in Development, Cancer and Other Cellular Processes
Daniela Boehm1, Kanika Khanna1, Zichong Li1
1Gladstone Infectious Disease Institute, Gladstone Institutes, San Francisco, CA 94158, USA.
International Journal of Molecular Sciences
|July 15, 2026
Summary
The lysine methyltransferase SMYD5 regulates development and is linked to various cancers and biological processes. This review highlights its epigenetic roles in development and disease.
Area of Science:
- Molecular Biology
- Epigenetics
- Developmental Biology
Background:
- SMYD5 is a lysine methyltransferase crucial for development.
- It is implicated in various malignancies including cancers and heart disease.
- SMYD5 also influences RNA translation and HIV-1 transcription.
Purpose of the Study:
- To review the literature on SMYD5.
- To focus on its epigenetic functions.
- To explore its roles in development, cancer, and other biological processes.
Main Methods:
- Literature review of scientific articles on SMYD5.
- Analysis of SMYD5's known methyltransferase targets.
- Examination of SMYD5's expression patterns and functional associations.
Main Results:
- SMYD5 methylates histone residues H3K36, H3K37, and H4K20.
- It also methylates non-histone targets like RPL40 and HIV-1 Tat.
- SMYD5 is widely expressed in various tissues and cell types.
Conclusions:
- SMYD5 is a key epigenetic regulator with diverse roles.
- Its dysregulation is associated with multiple diseases, including cancer.
- Further research into SMYD5 functions is warranted.
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