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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Jul 16, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

Interleukin-1β (C-511T) Genetic Variant and Major Depressive Disorder: A Systematic Review.

Bruna Rodrigues Gontijo1, Caroline Ferreira Fratelli1, Larissa Sousa Silva Bonasser2

  • 1Postgraduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 72220-900, Brazil.

International Journal of Molecular Sciences
|July 15, 2026
PubMed
Summary

The Interleukin-1β (IL-1β) C-511T genetic variant shows varied associations with Major Depressive Disorder (MDD). The CC genotype may link to increased symptom severity, while the TT genotype might predict antidepressant treatment response.

Keywords:
C-511T polymorphism (rs16944)Psychiatric geneticsantidepressant responsebiomarkerscytokines and inflammationgenetic variantinterleukin-1β (IL1β)major depressive disorder (MDD)neurodegenerationpersonalized medicine

Related Experiment Videos

Last Updated: Jul 16, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Major Depressive Disorder (MDD) is a complex condition with multifactorial causes.
  • Inflammatory responses and neurodegeneration are implicated in MDD pathogenesis.
  • Interleukin-1β (IL-1β), a cytokine, plays a role in immune and nervous system functions, including mood regulation.

Purpose of the Study:

  • To systematically review the association between the IL1B (C-511T) (rs16944) genetic variant and MDD.
  • To analyze CC and CT genotype frequencies in relation to MDD across diverse populations.
  • To evaluate the TT genotype's impact on antidepressant therapy response.

Main Methods:

  • Systematic review of five databases.
  • Article selection based on PECOS inclusion criteria.
  • Analysis of eight selected studies.

Main Results:

  • The CC genotype was more frequently associated with higher MDD symptom severity.
  • The TT genotype was predominantly linked to a positive response to antidepressant treatment.
  • Some studies found no significant association between the IL1B variant and MDD.

Conclusions:

  • The IL1B (C-511T) variant may have differential roles in MDD susceptibility and treatment response.
  • Associations between genotypes (CC vs. TT) and clinical outcomes are not equivalent.
  • Further research across varied populations is necessary to clarify the role of this polymorphism in MDD etiology.