Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses.

Autism research : official journal of the International Society for Autism Research·2026
Same author

Sex- and etiology-specific effects on predictive processing in the inferior colliculus of two rat models of autism.

Communications biology·2026
Same author

Cortical deviance detection represents a canonical difference signal.

bioRxiv : the preprint server for biology·2026
Same author

Dataset of Oddball Paradigm experiment in the Auditory Cortex and the effect of acetylcholine.

Scientific data·2026
Same author

Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.

Communications biology·2025
Same author

Design of Experiments (DoE)-Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose-to-Brain Delivery.

Small (Weinheim an der Bergstrasse, Germany)·2025

Related Experiment Video

Updated: Jul 16, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Subcortical Dendritic Scaffolding in Autism Spectrum Disorder: A Testable ANK2-SCN2A-SHANK Framework.

Sara Cacciato Salcedo1,2,3, Ana Belén Lao Rodriguez1,2,3, Marija M Petrinovic4,5,6

  • 1Cognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León, University of Salamanca, 37007 Salamanca, Spain.

International Journal of Molecular Sciences
|July 15, 2026
PubMed
Summary

Autism genes SCN2A, ANK2, and SHANK proteins form crucial dendritic scaffolds. Disrupting these scaffolds impacts neuronal integration, potentially contributing to autism spectrum disorder by altering excitatory signaling in brain circuits.

Keywords:
NaV1.2SHANK3amygdalaankyrin-Bautism spectrum disordercortico-subcortical circuitsdendritic integrationpostsynaptic densitystriatumthalamus

More Related Videos

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells
10:18

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells

Published on: October 10, 2015

Related Experiment Videos

Last Updated: Jul 16, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells
10:18

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells

Published on: October 10, 2015

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Autism spectrum disorder (ASD) is linked to mutations in SCN2A, ANK2, and SHANK genes.
  • Ankyrin-B (ANK2) scaffolds NaV1.2 (SCN2A) in neocortical neurons, crucial for dendritic integration.
  • SHANK proteins organize postsynaptic scaffolds, influencing receptor signaling and spine morphology.

Purpose of the Study:

  • To review evidence for dendritic scaffolding convergence in ASD.
  • To evaluate the role of these scaffolds beyond the cortex, in subcortical regions.
  • To propose testable hypotheses for experimental validation.

Main Methods:

  • Review of existing cortical evidence.
  • Assessment of striatum, thalamus, and amygdala for related mechanisms.
  • Proposal of experimental approaches including conditional gene deletion and imaging.

Main Results:

  • Ankyrin-B/NaV1.2 module is essential for dendritic excitability and synaptic function in cortical neurons.
  • SHANK proteins form complementary postsynaptic scaffolds.
  • The striatum is a key subcortical region with evidence for SCN2A and SHANK3 involvement.

Conclusions:

  • Dendritic shaft and spine scaffolds jointly regulate neuronal input-output gain.
  • Disruption of these scaffolds may contribute to ASD by destabilizing excitatory integration.
  • Further research is needed to validate these mechanisms in subcortical regions and human tissue.